PDK4 Rabbit Monoclonal Antibody

Description

EnkiLife offers the PDK4 Rabbit Monoclonal Antibody. This antibody reacts with Mouse,Rat species and is suitable for WB,FC,IP application. Alternative Names of Immunogen: AV005916. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,FC 1:50-1:100,IP 1:20-1:50 Background: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation.