PDL1 degrader-2

Description

PD-L1 degrader-2 Compound B3 is an orally active AUTAC degrader, that degrades PD-L1 through autophagy-lysosome pathway with a DC50 of 0.5 ?M. PD-L1 degrader-2 exhibits inhibitory activity against PD-1/PD-L1 interaction with an IC50 of 22.8 nM. PD-L1 degrader-2 upregulates the expressions of Atg9b, Lamp1 and Mitf, and activates the autophagy lysosome system. PD-L1 degrader- exhibits antitumor efficacy in CT26 mouse model. Pink: autophagy-lysosome activator HY-159894 ; Black: linker HY-W015088 ; Blue: PD-L1 ligand HY-169365