GENERAL CATALOGUE
PDZ1i
HY-124813 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-124813
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medchemexpress.com/pdz1i.htmlCatalog No: HY-124813
CAS No: 2083618-79-3
Category: JAK STAT Signaling
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PDZ1i 113B7 is a inhibitor of MDA-9/Syntenin, with selective binding to the PDZ1 domain. PDZ1i inhibits radiation-induced invasion of glioblastoma GBM cells, radiosensitizes GBM cells, and impairs GBM-related signaling pathways including Src/EphA2, EGFRvIII/FAK, and NF-?B . PDZ1i reduces radiation-induced secretion of invasion-related proteases MMP-2, MMP-9, ADAM9 . PDZ1i shows anti-tumor effects in nude mice bearing intracranial U1242-luc xenografts or GBM xenografts. PDZ1i can be used for the study of glioblastoma GBM , breast cancer and prostate cancer.