GENERAL CATALOGUE
Perenostobart
HY-P990068 · 1 mg
MedChemExpress · Cat: HY-P990068
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Catalog No: HY-P990068
CAS No: 2643331-31-9
Category: Immunology Inflammation
Pack Size: 1 mg
Brand: MedChemExpress
Description
Perenostobart SRF617 is a human IgG4 antibody with inhibitory activity against CD39 ATPase. Perenostobart inhibits CD39-mediated hydrolysis of extracellular ATP to AMP, with IC50 values of 1.9 nM HEK293 OE cells , 0.7 nM MOLP-8 cells , and 1.2 nM RBC-lysed whole blood . Perenostobart enhances CD4+ T-cell proliferation, promotes dendritic cell maturation, and boosts inflammasome activation in macrophages in the presence of ATP. Perenostobart demonstrates significant single-agent anti-tumor efficacy in MOLP-8 and H520 xenograft models. Perenostobart can be used for the study of cancer.
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