Peretinoin

Description

Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor RXR and retinoic acid receptor RAR . Peretinoin reduces the mRNA level of sphingosine kinase 1 SPHK1 in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis NASH and the development of hepatocellular carcinoma HCC through activating the autophagy pathway by increased Atg16L1 expression. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 ?M.