Peretinoin (Standard)

Description

Peretinoin Standard is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor RXR and retinoic acid receptor RAR . Peretinoin reduces the mRNA level of sphingosine kinase 1 SPHK1 in vitro by downregulating a transcription factor, Sp1 1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis NASH and the development of hepatocellular carcinoma HCC through activating the autophagy pathway by increased Atg16L1 expression 2 . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 ?M 3 .