Petosemtamab (FUT8-KO)

Description

Petosemtamab FUT8-KO is an anti-EGFR/LGR5 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene FUT8 knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Petosemtamab HY-P99406 is an anti-EGFR Kd: 0.22 nM and anti-LGR5 Kd: 0.86 nM monoclonal antibody mAb . Petosemtamab leads to blockade of EGFR signaling and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the study of solid tumors such as head and neck squamous cell carcinoma HNSCC , metastatic colorectal cancer CRC , etc.