GENERAL CATALOGUE
Pevonedistat hydrochloride
HY-10484 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-10484
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medchemexpress.com/MLN4924-hydrochloride.html
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Catalog No: HY-10484
CAS No: 1160295-21-5
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Pevonedistat MLN4924 hydrochloride is a potent and selective NEDD8-activating enzyme NAE inhibitor, with an IC50 of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice.
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