GENERAL CATALOGUE
PF-04995274
HY-18137 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-18137
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Catalog No: HY-18137
CAS No: 1331782-27-4
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PF-04995274 is a potent, high-affinity, orally active and partial serotonin 4 receptor 5-HT4R agonist. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E Ki range of 0.15-0.46 nM , and has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E Ki of 0.30 nM for rat 5-HT4S . PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimers disease.
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