GENERAL CATALOGUE
PF-06445974
HY-119190 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-119190
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Catalog No: HY-119190
CAS No: 2055776-17-3
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
PF-06445974, a promising positron emission tomography PET lead, has exquisite potency at PDE4B with an IC50 <1 nM. The IC50 values are 36, 4.7 and 17 nM for PDE4D, PDE4A and PDE4C, respectively. PF-06445974 has good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the cold tracer study.