GENERAL CATALOGUE
PF-3450074
HY-120072 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-120072
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medchemexpress.com/pf-3450074.htmlCatalog No: HY-120072
CAS No: 1352879-65-2
Category: Anti-infection
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
PF-3450074 PF-74 is a specifical inhibitor of HIV-1 capsid protein CA and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency EC50=8-640 nM . PF-3450074 PF-74 acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
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