GENERAL CATALOGUE
PF 477736
HY-10032 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-10032
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medchemexpress.com/PF-477736.htmlCatalog No: HY-10032
CAS No: 952021-60-2
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PF 477736 PF 00477736 is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows 100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret IC50=8 Ki , 10, 14, 23, 23, 25, and 39 nM, respectively . PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.
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