GENERAL CATALOGUE
PF-543
HY-15425 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-15425
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medchemexpress.com/PF-543.html
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Catalog No: HY-15425
CAS No: 1415562-82-1
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PF-543 Sphingosine Kinase 1 Inhibitor II is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate S1P formation in whole blood with an IC50 of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy.
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