GENERAL CATALOGUE
PF-543 hydrochloride
HY-15425B · 50 mg
MedChemExpress · Cat: HY-15425B
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medchemexpress.com/pf-543-hydrochloride.htmlCatalog No: HY-15425B
CAS No: 1706522-79-3
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
PF-543 hydrochloride Sphingosine Kinase 1 Inhibitor II hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate S1P formation in whole blood with an IC50 of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.
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