GENERAL CATALOGUE
PF-6274484
HY-101450 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-101450
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Catalog No: HY-101450
CAS No: 1035638-91-5
Category: JAK STAT Signaling
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively.
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