GENERAL CATALOGUE
PF-915275
HY-18056 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-18056
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Manufacturer product page
medchemexpress.com/PF-915275.htmlCatalog No: HY-18056
CAS No: 857290-04-1
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
PF-915275 is a potent, selective and orally active human 11?-hydroxysteroid dehydrogenase type 1 11?HSD1 inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM in HEK293 cells . The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.
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