Phellopterin

Description

Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 reducing chronic inflammation, aiding diabetic ulcer healing , inhibiting STAT3 phosphorylation easing atopic dermatitis inflammation , regulating Akt/PKC pathways lowering TNF-?-induced VCAM-1 to block monocyte adhesion , and inhibiting TLR4/NF-?B pathway and macrophage M2 polarization alleviating colitis-related cancers . Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop inducing cell cycle arrest, apoptosis, DNA damage . Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPAR?. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer e.g., ovarian cancer, colitis cancer , blood glucose lowering, anti-diabetes, and anti-virus.