Phospho-Chk2 (Thr68) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-Chk2 (Thr68) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,ICC/IF application. Alternative Names of Immunogen: CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200 Background: These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function. Research Area: Epigenetics and Nuclear Signaling