Phospho-Csk (Ser364) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-Csk (Ser364) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000 Background: catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases. PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro. similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. similarity:Contains 1 protein kinase domain. similarity:Contains 1 SH2 domain. similarity:Contains 1 SH3 domain. subcellular location:Mainly cytoplasmic, also present in lipid rafts. subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1. tissue specificity:Expressed in lung and macrophages. Research Area:Chemokine;Neurotrophin;Regulates Actin and Cytoskeleton;Epithelial cell signaling in Helicobacter pylori infection;