Phospho-HDAC5 (Ser498) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-HDAC5 (Ser498) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for WB,IHC application. Alternative Names of Immunogen: HD5; NY-CO-9. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:50-1:100 Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Research Area: Epigenetics and Nuclear Signaling