Phospho-Histone H3.3 (Ser31) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-Histone H3.3 (Ser31) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B; Histone H3.3. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:10000-1:20000 Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008],developmental stage:Expressed throughout the cell cycle independently of DNA synthesis.,function:Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Research Area: Protein_Acetylation