Phospho-JAK2 (Tyr1007) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-JAK2 (Tyr1007) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,ELISA application. Alternative Names of Immunogen: JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:50-1:100,ELISA 1:5000-1:20000 Background: Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Research Area: Cell Biology