Phospho-p107 (Thr369) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-p107 (Thr369) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for IHC,ELISA application. Alternative Names of Immunogen: PRB1; p107; CP107. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:50-1:100,ELISA 1:5000-1:20000 Background: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. Research Area: Cell Biology