Phospho-PLB (Ser16/T17) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-PLB (Ser16/T17) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC application. Alternative Names of Immunogen: PLN; PLB; Cardiac phospholamban; PLB. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:50-1:300 Background: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016],disease:Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.,PTM:Phosphorylated in response to beta-adrenergic stimulation.,similarity:Belongs to the phospholamban family.,subunit:Homopentamer.,tissue specificity:Heart., Research Area: Calcium;Dilated cardiomyopathy;