Phospho-XPA (Phospho-Ser196) Rabbit Polyclonal Antibody

Description

EnkiLife offers the Phospho-XPA (Phospho-Ser196) Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB application. Alternative Names of Immunogen: DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein). The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000 Background: disease:Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.,function:Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the XPA family.,subunit:Interacts with XAB1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation.,tissue specificity:Expressed in various cell lines and in skin fibroblasts.,