GENERAL CATALOGUE
Phthalazinone pyrazole
HY-12564 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-12564
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Catalog No: HY-12564
CAS No: 880487-62-7
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 ?M. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition EMT during the differentiation of hepatocyte-like cells HLCs from human embryonic stem cells.
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