GENERAL CATALOGUE
PHTPP-1304
HY-161740 · 1 mg
MedChemExpress · Cat: HY-161740
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Catalog No: HY-161740
CAS No: 2410081-60-4
Category: Autophagy
Pack Size: 1 mg
Brand: MedChemExpress
Description
PHTPP-1304 is a PHTPP-based autophagy targeting chimera AUTOTAC . PHTPP-1304 induces the degradation of estrogen receptor ER? through the autophagy pathway, rather than ubiquitination DC50 ? 2 nM, in HEK293T cells; < 100 nM in ACHN renal carcinoma and MCF-7 breast cancer cells . PHTPP-1304 can induce the self-oligomerization of p62. PHTPP-1304 can be used to study various cancers mediated by ER?.
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