PI3K/HDAC-IN-4

Description

PI3K/HDAC-IN-4 Compound 31f is a PI3K/HDAC dual inhibitor IC50: 0.2?M . PI3K/HDAC-IN-4 shows high selectivity for HDAC1-3 IC50 values of 75.5 nM, 70.9 nM, and 1.9 nM, respectively . PI3K/HDAC-IN-4 is a potent PIK3 inhibitor with IC50 values of 2.5 nM, 80.5 nM, 10.0 nM, and 57.2 nM for PI3K?, ?, ?, and ?, respectively. PI3K/HDAC-IN-4 significantly induces tumor cell apoptosis by simultaneously inhibiting the PI3K/AKT/mTOR signaling pathway and HDAC1-3. PI3K/HDAC-IN-4 exhibits potent antiproliferative activity in a variety of tumor cell lines e.g., MV4-11, Jeko-1, HL60, and MCF-7, with IC50 values of 0.2, 0.9, 0.8, and 1.5 ?M, respectively . PI3K/HDAC-IN-4 can be used in the study of lymphoma and leukemia.