GENERAL CATALOGUE
PI3K?-IN-25
HY-175369 · 50 mg
MedChemExpress · Cat: HY-175369
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Catalog No: HY-175369
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
PI3K?-IN-25 is an orally active selective PI3K? inhibitor IC50 = 2.1 nM . PI3K?-IN-25 has IC50s of 272, 285, and 1171 nM for PI3K?, PI3K?, and PI3K?, respectively. PI3K?-IN-25 inhibits AKT Ser473 phosphorylation, suppresses Treg cell proliferation, and downregulates PD-L1 expression in B16F10 cells. PI3K?-IN-25 exhibits anticancer effects in B16F10 melanoma and Lewis lung cancer mouse models by reducing tumor-infiltrating Treg cells and enhancing immune responses. PI3K?-IN-25 is potentially useful in the study of melanoma, lung cancer, and other cancers.
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