PI3K-IN-58

Name: PI3K-IN-58
Brand: MedChemExpress

HY-172886 · 50 mg

MedChemExpress · Cat: HY-172886

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Catalog No: HY-172886

CAS No: 3067572-78-2

Category: Apoptosis

Pack Size: 50 mg

Brand: MedChemExpress

Description

PI3K-IN-58 Compound 17f is a PI3K? inhibitor IC50: 0.039 ?M . PI3K-IN-58 exhibits significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231 and MDA-MB-453 cell lines with IC50s of 3.48 ?M, 1.06 ?M, 2.21 ?M and 0.93 ?M, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression levels of anti-apoptotic proteins Bcl-XL and Bcl-2 and upregulating the expression of anti-apoptosis protein BAX. PI3K-IN-58 can be used in PI3K-targeted cancer research.