PI3K-IN-59

Description

PI3K-IN-59 Compound 3d is a PI3K inhibitor IC50: 17.44 ?M . PI3K-IN-59 has significant antiproliferative activity and exhibits potent inhibitory effects on breast cancer 4T1 cells IC50: 3.70 ?M and colon cancer CT26 cells IC50: 1.98 ?M as well as human breast cancer cells IC50: 19.72 ?M . PI3K-IN-59 exerts a dual anti-tumor mechanism by inhibiting PI3K? enzymatic activity and triggering the Fenton reaction to generate hydroxyl radicals AAasAasAaOH . PI3K-IN-59 shows promising anti-4T1 tumor effects and is suitable for synergistic targeting studies in breast and colon cancers.