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PI3K/mTOR-IN-17
GENERAL CATALOGUE

PI3K/mTOR-IN-17

HY-174855 · 50 mg

MedChemExpress · Cat: HY-174855

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Catalog No: HY-174855
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

PI3K/mTOR-IN-17 is a dual PI3K and mTOR inhibitor with IC50 values of 1.21 ?M PI3K , and 0.21 ?M mTOR . PI3K/mTOR-IN-17 induces cells caspase-mediated apoptosis by arresting their growth in the G1-phase. PI3K/mTOR-IN-17 upregulates the levels of caspases-3, 7, 8, and 9, p53 expression and Bax/Bcl-2 ratio. PI3K/mTOR-IN-17 suppresses the PI3K/mTOR signaling pathway. PI3K/mTOR-IN-17 can be used for research of cancer, such as non-small cell lung cancer NSCLC .

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