Picolinafen

Description

Picolinafen is a pyridine-class herbicide that acts as a phytoene desaturase PDS inhibitor. Picolinafen effectively controls broadleaf weeds and disrupts carotenoid biosynthesis. Picolinafen exhibits cytotoxicity to porcine trophectoderm pTr and luminal epithelial pLE cells. Picolinafen induces ROS accumulation, calcium depletion, and activates MAPK and PI3K signaling pathways, leading to decreased cell viability, increased apoptosis, impaired migration, and altered expression of implantation-related genes. Picolinafen has an LD50 value of 2.7 mg/kg in mammals and 7 ?g/L in fish. Picolinafen exhibits toxic effects during zebrafish embryogenesis1 2 .