GENERAL CATALOGUE
PIK5-12d
HY-155994 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-155994
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medchemexpress.com/pik5-12d.htmlCatalog No: HY-155994
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PIK5-12d is a PROTAC PIKfyve degrader DC50 = 1.48 nM . PIK5-12d induces massive cytoplasmic vacuolization and blocks autophagic flux in multiple prostate cancer cells. PIK5-12d inhibits prostate cancer cell proliferation. PIK5-12d significantly suppresses tumor proliferation in mice bearing LTL-331R human prostate cancer PDX tumors. PIK5-12d can be used for the study of prostate cancer. Pink: PIKfyve ligand HY-175631 , Blue: VHL Ligand HY-125845 , Black: Linker, PIKfyve ligand-linker conjugate HY-175632 .
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