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PKUMDL-WQ-2201
GENERAL CATALOGUE

PKUMDL-WQ-2201

HY-123418 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-123418

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Catalog No: HY-123418
CAS No: 592474-91-4
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor IC50=35.7 ?M . PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC50s of 69 ?M T59A and >300 ?M T56AK57A , respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth.

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