PLK1-IN-13

Description

PLK1-IN-13 is a selective and orally active PLK1 inhibitor IC50: 0.27 nM . PLK1-IN-13 also inhibits PLK2 IC50: 12.72 nM and PLK3 IC50: 4.12 nM . PLK1-IN-13 arrests cell at G2 phase, induces apoptosis and down-regulates the transcription of the proliferation-related oncogene c-MYC. PLK1-IN-13 inhibits tumor growth, and can be used for research of acute myeloid leukemia AML .