GENERAL CATALOGUE
PLX-3618
HY-161779 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-161779
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medchemexpress.com/plx-3618.html
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Catalog No: HY-161779
CAS No: 2851986-76-8
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PLX-3618 is a molecular glue, that degrades BRD4 with DC50 of 12.2 nM. PLX-3618 promotes polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting of the E3 ligase substrate receptor, DCAF11. PLX-3618 inhibits the proliferation of various cancer cells, induces apoptosis in AML cells. PLX-3618 exhibits antitumor activity against AML in mouse models.
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