GENERAL CATALOGUE
PMMB-187
HY-164521 · 50 mg
MedChemExpress · Cat: HY-164521
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Manufacturer product page
medchemexpress.com/pmmb-187.htmlCatalog No: HY-164521
CAS No: 2162952-37-4
Category: JAK STAT Signaling
Pack Size: 50 mg
Brand: MedChemExpress
Description
PMMB-187 is a selective STAT3 inhibitor with an IC50 value of 1.81 ?M for MDA-MB-231 cells. PMMB-187 induces apoptosis Apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity, nuclear translocation, and downstream target gene expression, while also reducing mitochondrial membrane potential, generating reactive oxygen species ROS , and upregulating the expression levels of apoptosis-related proteins. PMMB-187 has potential applications in cancer research.
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