PNR-7-02

Description

PNR-7-02 inhibits Pol ? function with an IC50 value of near 8 ?M, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda ? . PNR-7-02 acts synergistically with Cisplatin HY-17394 to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid ITBA derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring.