GENERAL CATALOGUE
PNU-292137
HY-123045 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-123045
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Manufacturer product page
medchemexpress.com/pnu-292137.htmlCatalog No: HY-123045
CAS No: 326823-27-2
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PNU-292137 is an orally active, potent CDK2 inhibitor with IC50s of 37 nM and 92 nM for CDK2/cyclin A and CDK2/cyclin E, respectively. PNU-292137 makes interactions with the hydrophobic pocket at the back of the CDK2 ATP pocket. PNU-292137 efficiently inhibits tumor cell proliferation in human colon and prostate tumor cell lines. PNU-292137 exhibits antitumor activity TGI 50 % in a mouse xenograft model.
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