GENERAL CATALOGUE
Poloppin
HY-124761 · 1 mg
MedChemExpress · Cat: HY-124761
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medchemexpress.com/poloppin.htmlCatalog No: HY-124761
CAS No: 683808-78-8
Category: Autophagy
Pack Size: 1 mg
Brand: MedChemExpress
Description
Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase PLK IC50=26.9 ?M and prevents the protein-protein interaction via the Polo-box domain PBD Kd= 29.5 ?M . Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors.
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