Poloxipan

Description

Poloxipan is a pan-specific polo-like kinase PLK inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain PBD found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 ?M, 1.7 ?M, and 3.0 ?M, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated FHA domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase PIN1 , and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinases SH2 domain. Poloxipan can be used in cancer research.