

RP-D00004 · 20 ug
GenScript · Cat: RP-D00004
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Manufacturer product page
genscript.com/protein/RP_D00004-POLQ.html
Description
Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining MMEJ , an alternative non-homologous end-joining NHEJ machinery required to repair double-strand breaks in DNA during mitosis. POLQ is often overexpressed in various cancers, especially those with HR deficiencies, such as BRCA1/2-mutated cancers.
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