Polyquaternium-1

Description

Polyquaternium-1 Polidronium chloride; PQ-1 is an antimicrobial preservative and an activator of NF-?B. Polyquaternium-1 targets bacterial cell membranes, commonly used in ophthalmic surgery. Polyquaternium-1 adsorbs to the surface of microbial membranes through its polycationic properties, destroying membrane integrity and inducing potassium ion leakage, leading to bacterial death. Polyquaternium-1 exerts antimicrobial effects at a concentration of 0.001 % and has low toxicity to mammalian cells. Polyquaternium-1 can be used to prepare products such as glaucoma eye drops Travoprost preparations containing PQ-1 , artificial tears, and contact lens solutions to reduce the ocular surface toxicity of traditional preservatives such as benzalkonium chloride HY-B2232 .