GENERAL CATALOGUE
Pomalidomide-C5-Dovitinib
HY-139996 · 50 mg
MedChemExpress · Cat: HY-139996
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Manufacturer product page
medchemexpress.com/pomalidomide-c5-dovitinib.htmlCatalog No: HY-139996
CAS No: 2732969-67-2
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
Pomalidomide-C5-Dovitinib compound 2 is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia.
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