GENERAL CATALOGUE
Poziotinib
HY-15730 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-15730
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Manufacturer product page
medchemexpress.com/Poziotinib.htmlCatalog No: HY-15730
CAS No: 1092364-38-9
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Poziotinib HM781-36B is an orally active, irreversible pan-HER inhibitor, which effectively inhibits EGFRwt, HER-2 and HER-4 with IC50s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib HM781-36B also shows excellent inhibitory activities against mutated EGFRs, including EGFRT790M and EGFRL858R/T790M, with IC50s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity.
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