GENERAL CATALOGUE
PP-C8
HY-144691 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-144691
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Catalog No: HY-144691
CAS No: 3032108-74-7
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PP-C8 is a potent and selective PROTAC CDK12-Cyclin K degrader. PP-C8 induces CDK12-Cyclin K degradation with DC50s of 416 and 412 nM for CDK12 and Cyclin K, respectively. PP-C8 demonstrates profound synergistic antiproliferative effects with PARP inhibitor in triple-negative breast cancer TNBC .
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