PPIA-IN-1

Description

PPIA-IN-1 Compound 20b is the inhibitor for peptidylprolyl isomerase A PPIA with a KD of 0.52 ?M. PPIA-IN-1 exhibits antiproliferative activity in a variety of cancer cell lines IC50 for HCT116 is 0.69 ?M , arrests the cell cycle at G0/G1 phase, and exhibits anti-metastatic effect in cell HCT116. PPIA-IN-1 increases ROS, causes DNA damage, ER stress and mitochondrial dysfunction, inducing apoptosis in HCT116 through MAPK pathway. PPIA-IN-1 exhibits antitumor activity in mouse CT26 xenograft models.