pQCXIX Retroviral Vector

Description

The pQCXIX Retroviral Vector is a self-inactivating retroviral expression vector that is optimized to eliminate promoter interference from the upstream LTR in the integrated provirus. It expresses two target genes from a single, bicistronic message. The CMV promoter present in the 5 LTR produces high viral titers in standard packaging cell lines. A deletion in the 3 LTR provides the self-inactivating feature after reverse transcription of the expression cassette. This vector is useful for applications in which high titers and high-level bicistronic gene expression are desired. Our products are to be used forResearch Use Only. They may not be used for any other purpose, including, but not limited to, use in humans, therapeutic or diagnostic use, or commercial use of any kind. Our products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products or to provide a service to third parties without our prior written approval. Back Composite retroviral vector map of Retro-X Q Vector Set SetIn this generalized version of the Q Vector Map, the common elements of all the vectors are represented. Immediately downstream of the CMV immediate early promoter, the multiple cloning site MCS is followed by a eukaryotic IRES that ensures a second ORF an antibiotic resistance marker or another gene in the case of pQCXIX is cotranscribed with the gene cloned into the MCS. The expression cassette has all of the essential elements for retroviral integration and expression. Back Back