GENERAL CATALOGUE
PR280
HY-163472 · 50 mg
MedChemExpress · Cat: HY-163472
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Catalog No: HY-163472
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
PR280 is a potent inhibitor of dihydroceramide desaturase 1 Des1 IC50=700 nM . PR280 forms hydrogen bonds with the amino acid residues of Des1, and its cyclopropenone group may form a coordination with the iron center, thus stabilizing the binding to the active site of Des1 and inhibiting the sphingosine lipid synthesis pathway of dihydroceramide dhCer to form ceramide. PR280 can be used in the study of diseases related to sphingosine lipid metabolism, such as cancer and metabolic diseases.
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